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generalized replica exchange with solute tempering of selected surface charged residues  (GRest Inc)

 
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    Structured Review

    GRest Inc generalized replica exchange with solute tempering of selected surface charged residues
    Generalized Replica Exchange With Solute Tempering Of Selected Surface Charged Residues, supplied by GRest Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/selected+surface+charged+residues/generalized+replica+exchange+with+solute+tempering+of+selected+surface+charged+residue++grest+sscr+/pmc08963885-39-14-15
    Average 90 stars, based on 1 article reviews
    generalized replica exchange with solute tempering of selected surface charged residues - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Sampling:

    Article Title: Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations
    Article Snippet: This scheme, gREST selected surface charged residues (gREST_SSCR), does not affect the intradomain conformational stability significantly, while it can enhance the relative domain motions to describe conformational transitions on the FEL more efficiently and accurately.

    Article Title: Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling
    Article Snippet: This approach, which we refer to as gREST selected surface charged residues (gREST_SSCR), has two advantages compared to the conventional MD (cMD) and other enhanced sampling methods: (i) The intra-domain interactions remain intact, keeping the conformational stability of each domain even at high solute temperatures; only relative domain motions can be enhanced in gREST_SSCR. (ii) The number of atoms in the solute region is much smaller than conventional REST/REST2, reducing the number of replicas.

    Article Title: Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations.
    Article Snippet: Conformational changes of proteins upon ligand binding are usually explained in terms of several mechanisms including the induced fit, conformational selection, or their mixtures.. Due to the slow time scales, conventional molecular dynamics (cMD) simulations based on the atomistic models cannot easily simulate the open-to-closed conformational transition in proteins.. In our previous study, we have developed an enhanced sampling scheme (generalized replica exchange with solute tempering selected surface charged residues: gREST_SSCR) for multidomain proteins and applied it to ligand-mediated conformational changes in the G134R mutant of ribose-binding protein (RBPG134R) in solution.

    Article Title: Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling
    Article Snippet: This approach is called gREST selected surface charged residues (gREST_SSCR) and is applied to the Apo and Holo states of ribose binding protein (RBP) in solution.

    Binding Assay:

    Article Title: Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations
    Article Snippet: This scheme, gREST selected surface charged residues (gREST_SSCR), does not affect the intradomain conformational stability significantly, while it can enhance the relative domain motions to describe conformational transitions on the FEL more efficiently and accurately.

    Article Title: Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling
    Article Snippet: This approach, which we refer to as gREST selected surface charged residues (gREST_SSCR), has two advantages compared to the conventional MD (cMD) and other enhanced sampling methods: (i) The intra-domain interactions remain intact, keeping the conformational stability of each domain even at high solute temperatures; only relative domain motions can be enhanced in gREST_SSCR. (ii) The number of atoms in the solute region is much smaller than conventional REST/REST2, reducing the number of replicas.

    Article Title: Unraveling the Coupling between Conformational Changes and Ligand Binding in Ribose Binding Protein Using Multiscale Molecular Dynamics and Free-Energy Calculations.
    Article Snippet: Conformational changes of proteins upon ligand binding are usually explained in terms of several mechanisms including the induced fit, conformational selection, or their mixtures.. Due to the slow time scales, conventional molecular dynamics (cMD) simulations based on the atomistic models cannot easily simulate the open-to-closed conformational transition in proteins.. In our previous study, we have developed an enhanced sampling scheme (generalized replica exchange with solute tempering selected surface charged residues: gREST_SSCR) for multidomain proteins and applied it to ligand-mediated conformational changes in the G134R mutant of ribose-binding protein (RBPG134R) in solution.

    Article Title: Exploring Large Domain Motions in Proteins Using Atomistic Molecular Dynamics with Enhanced Conformational Sampling
    Article Snippet: This approach is called gREST selected surface charged residues (gREST_SSCR) and is applied to the Apo and Holo states of ribose binding protein (RBP) in solution.



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